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Tapentadol
Aspadol

  • Nucynta / Palexia / TAPAL
  • PAR003
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $16.41 ! Buying from us will save you at least 40.46%

Package per pill Price SAVINGS BONUS Order
100mg * 30 pills
$9.77 $293.10 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
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►Next orders 10% discount
100mg * 60 pills
$5.89 $353.40 $232.80
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for orders between $300 & $550
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100mg * 90 pills
$4.89 $440.10 $439.20
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
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►Next orders 10% discount
►Free 10 bonus pills
100mg * 120 pills
$4.69 $562.80 $609.60
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
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►Next orders 15% discount
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100mg * 180 pills
$3.59 $646.20 $1,112.40
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
►Package delivery insurance
►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers

   Manufacturer's Suggested Retail Price (MSRP) per pill is $18.60 ! Buying from us will save you at least 39.41%

Package per pill Price SAVINGS BONUS Order
200mg * 30 pills
$11.27 $338.10 $0.00
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free 10 bonus pills
200mg * 60 pills
$6.69 $401.40 $274.80
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free 10 bonus pills
200mg * 90 pills
$5.69 $512.10 $502.20
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free 10 bonus pills
200mg * 120 pills
$5.19 $622.80 $729.60
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
►Package delivery insurance
►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers
200mg * 180 pills
$4.09 $736.20 $1,292.40
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
►Package delivery insurance
►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers

   Manufacturer's Suggested Retail Price (MSRP) per pill is $11.00 ! Buying from us will save you at least 40.45%

Package per pill Price SAVINGS BONUS Order
100mg * 30 pills
$6.55 $196.50 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 60 pills
$4.85 $291.00 $102.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 90 pills
$4.19 $377.10 $212.40
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free standard airmail service
100mg * 120 pills
$3.97 $476.40 $309.60
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
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►Next orders 10% discount
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100mg * 180 pills
$3.31 $595.80 $583.20
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
►Package delivery insurance
►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers

   Manufacturer's Suggested Retail Price (MSRP) per pill is $16.41 ! Buying from us will save you at least 66.97%

Package per pill Price SAVINGS BONUS Order
100mg * 30 pills
$5.42 $162.60 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 60 pills
$3.96 $237.60 $87.60
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 90 pills
$3.52 $316.80 $171.00
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free standard airmail service
100mg * 120 pills
$3.36 $403.20 $247.20
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free standard airmail service
100mg * 180 pills
$2.98 $536.40 $439.20
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
►Package delivery insurance
►Next orders 10% discount
►Free standard airmail service

Tapentadol is a centrally acting opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.

The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.

Tapentadol is used for the treatment of moderate to severe pain for both acute (following injury, surgery, etc.) and chronic musculoskeletal pain. It is also specifically indicated for controlling the pain of diabetic neuropathy when around-the-clock opioid medication is required.

Tapentadol is a centrally-acting synthetic analgesic that is 18 times less potent than morphine in binding mu-opioid receptors. It also increases norepinephrine concentrations in the brains of rats via inhibition of norepinephrine reuptake.

Selective mu-opioid antagonists like naloxone can block analgesia from tapentadol. It also has not effect on the QT interval.

Tapendadol causes large increases in levels of extracellular norepinephrine (NE) due to a dual mechanism of action involving mu opioid receptor (MOR) agonism as well as noradrenaline reuptake inhibition.

Tapentadol is a μ opioid receptor agonist and a noradrenaline (norepinephrine) reuptake inhibitor. These opioidergic and noradrenergic activities are believed to account for the analgesic effects of the drug. Tapentadol is also a weak serotonin reuptake inhibitor; however, this weak serotonergic activity is not thought to be relevant with regard to the drug’s analgesic activity.

Metabolism: 97% of the dose is metabolized mostly via conjugation with glucuronic acid to produce glucuronides. Tapentadol is also metabolized into N-desmethyl tapentadol (13%) by CYP2C9 and CYP 2C19. CYP2D6 is involved in the formation of the metabolite, hydroxy tapentadol (2%). All metabolites are inactive.

Absorption: Bioavailability, immediate release in 1.5 hours; Bioavailability, extended release in 5.0 hours; Tapentadol accumulates following multiple repeat doses.

Route of elimination: Tapentadol and its metabolites are excreted almost exclusively (99%) via the kidneys. Approximately 70% (55% O-glucuronide and 15% sulfate of tapentadol) is excreted in conjugated form. A total of 3% of drug was excreted in urine as unchanged drug.

Half life: Elimination half-life, IV: 4 hours.

All medicines may cause side effects, but many people have no, or minor, side effects. Some medical conditions may interact with Tapentadol.

Tell your doctor or pharmacist if you have any medical conditions.

The most common reasons for discontinuation due to adverse events were dizziness, nausea, vomiting, somnolence, and headache.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Jessie
30/Apr/2024

I love this product! I was in severe pain until I started taking Tapentadol. Right away I like felt the pain go away - it was like the first time I heard the Beatles. Thank you so much guys for this product.

Norma
30/Apr/2024

Tried everything to help with pain over the weekend. Took Tapentadol and within half hour was able to function again without the pain. Would recommend to anyone suffering chronic pain. Tip: It's the Extended Release version!

Terry
19/Mar/2024

Have severe lower back pain, have been on various pain pills, and opiates finally I was prescribed tapentadol twice a day in the a.m. and p.m. and it works quick. I have been on this program for about 5 years now with no side effects and the pain is now controlled.

Margie
06/Jan/2024

Within 10-15 min pain is gone for good. I suffer from chronic headaches/migraines my whole life... it's my life saver. It's my best friend for sure.

Zane
20/Dec/2023

YES! This is my choice medication. I have a lot of joint pain which I deal with without any drugs, but when it gets too bad Tapentadol works well and works fast, and let's just say when I injured my back it was a life saver. I just recently got burned on my leg (at a Spa, not very relaxed). I've had minor swelling and Tapentadol has reduced the swelling/pain. Would not recommend taking it on an empty stomach... If you're healthy enough to take it I would definitely recommend it. Works just great.

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